Although consciousness-correlated physical phenomena are widely and credibly documented, their appearance and behavior display substantial departures from conventional scientific criteria. Under even the most rigorous protocols, they are only irregularly replicable, and they appear to be insensitive to most basic physical coordinates, including distance and time. Rather, their strongest correlations are with various subjective parameters, such as intention, emotional resonance, uncertainty, attitude, and meaning, and information processing at an unconscious level appears to be involved. If science, by its most basic definition, is to pursue understanding and utilization of these extraordinary processes, it will need to expand its current paradigm to acknowledge and codify a proactive role for the mind in the establishment of physical events, and to accommodate the spectrum of empirically indicated subjective correlates. The challenges of quantitative measurement and theoretical conceptualization within such a ‘‘Science of the Subjective’’ are formidable, but its potential intellectual and cultural benefits could be immense, not least of all in improving the reach, the utility, the attitude, and the image of science itself.